Supply High Purity 99% Memantine CAS 41100-52-1 Memantine HCl

• Powder: Yes
• Customized: Non-Customized
• State: Solid
• Purity: >98%
• Shipping: FedEx TNT UPS DHL
• Shelf Time: 2 Years
• Model NO.: CAS 41100-52-1
• Color: White
• Stock: Yes
• Test Report: HPLC Nmr COA Lcms
• Transport Package: Al-Foil Bag
• Specification: 1bags
• Trademark: HHD
• Origin: China
• Production Capacity: 1000bags

Product Description

 

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Product Name	Memantine Hydrochloride
CAS NO.	41100-52-1
Purity	99%
Density	0.8030
Appearance and shape	White powder

Memantine hydrochloride is a dementia treatment drug developed by the German Merz company. It is a new, low-to-moderate affinity, voltage-dependent, non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It can block NMDA receptors non-competitively, reduce the excessive excitement of NMDA receptors caused by glutamate, prevent cell apoptosis, and improve memory. It is a new generation of drugs to improve cognitive function. In February 2002, the European Patent Medicines Committee (CPMP) approved it for the treatment of patients with moderate and severe Alzheimer's disease. It was launched in Germany in August of the same year and was approved by the US Food and Drug Administration on October 17, 2003 FDA) approved for the treatment of patients with moderate to severe Alzheimer's disease. Further studies have shown that memantine hydrochloride is also effective for patients with mild to moderate Alzheimer's disease. Alzheimer's disease (Alzheimerdisease, AD), also known as senile dementia, is one of the common diseases of the elderly, mainly manifested as memory loss and recognition impairment, and it is a progressive neurodegenerative disease. Cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and memantine hydrochloride are approved for the treatment of Alzheimer's disease.


1)Memantine hydrochloride is a moderate affinity of the non-competitive N-methyl-D-aspartate (NMDA),
a major role in the brain glutamine system, is the first of Alzheimer's disease and vascular dementia have 
a significant effect of NMDA antagonists.
2)Memantine hydrochloride while neuropathic pain, chorea and AIDS dementia caused curative. 

Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical. The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.

1. Drugs for dementia
The US FDA approved in October 2003 as the only treatment for severe Alzheimer's disease. It is well tolerated and has a significant effect on severe Alzheimer's disease.
2. Combined use with Huperzine A
Huperzine A is a medicine extracted from the traditional Chinese medicine Huperzia serrata. It is a reversible competitive cholinesterase inhibitor. Memantine has different binding abilities to different glutamate receptor subtypes or ion channels, reducing the excitotoxic effects of glutamate, thereby treating AD.
3. Combined use with donepezil
Donepezil is a second-generation cholinesterase inhibitor with higher selectivity for central nervous system cholinesterase, a long half-life, and lower toxicity than Huperzine A. Donepezil and Huperzine A act on different nerve conduction systems. When the two are used in combination, they can produce a synergistic effect, thereby enhancing the efficacy.
4. Combined use with nimodipine
Nimodipine is a dihydropyridine Ca2+ antagonist. It can act on nerve cells, cerebrovascular cells and glial cells of the central nervous system, and can significantly expand the diameter of cerebral blood vessels and meningeal blood vessels, which can delay the recognition of patients to a certain extent. Know the decline.
5. Combined use with ginkgo biloba
The main components of Ginkgo biloba are flavonoids and nightshade lactone compounds, which have antithrombotic, anticoagulant, anti-platelet aggregation, anti-oxidation and lipid-regulating effects, improve blood vessel wall permeability and reduce brain damage, and protect brain microvascular smooth muscle cells. It has an obvious protective effect on "vascular damage".

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