| Product Name |
Pharmaceutical Intermediate Nootropics GTS-21 156223-05-1 pure GTS-21 powder price |
| Appearance |
White powder |
| Molecular formula |
C19h22cl2n2o2 |
| Molecular Weight |
308.374 |
| Keywords |
GTS-21 price,pure GTS-21 powder,Pharmaceutical Intermediate GTS-21 |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
What is GTS-21?
GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals.
Nootropics also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, andhormones), by improving the brain's oxygen supply, or by stimulating nerve growth.
GTS-21 has a high affinity for the rodent α7nAChR but its affinity for human α7nAChR is described to be low. Its metabolite, 4OH-(GTS-21) has been described to be a selective partial agonist with greater efficacy for both human and rat α7nAChRs (Conejero-Goldberg et al., 2008, Kem, 2000).
Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21[3] display nootropic[4] and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease,nicotine dependence,and, most significantly, for schizophrenia.
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