Wuhan HHD Supply Nootropis Powder Donepezil Hydrochloride CAS 120011-70-3 Raw Chemicals Pharmaceutical Intermediates
Chemical Name:donepezil hydrochloride
Application:antimuscarinic
Donepezil hydrochloride
Molecular Formula:C24H30ClNO3
Formula Weight:415.95
CAS:120011-70-3
Purity:99%
Appearance:white powder
Introduction:
ARICEPT (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1Hinden- 1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96.
Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs, compared with similar drugs have a low incidence of adverse reactions and efficacy obvious feature is the only way to reach the U.S. Food and Drug Administration standard treatment guidelines for Alzheimer's disease drug, is the only one species while the FDA approved the listing of new drugs and UK MCA for the treatment of mild to moderate Alzheimer's.
Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs. AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons, such cholinergic theory has been confirmed by histological study.
Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites. Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide, neurotransmitter receptors, or Ca2 + channels.
Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger, it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect, probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.
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