| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 757.0±60.0 °C at 760 mmHg |
| Molecular Formula | C30H29ClN6O3 |
| Molecular Weight | 557.043 |
| Flash Point | 411.6±32.9 °C |
| Exact Mass | 556.198975 |
| PSA | 112.40000 |
| LogP | 5.46 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.667 |
Neratinib is an irreversible epidermal grow factor receptor (EGFR) inhibitor. It is a small molecule tyrosine kinase inhibitor targeting HER2 and HER1 after lapatinib. It is an irreversible pan erbB receptor tyrosine kinase inhibitor. It can selectively inhibit HER-1 and HER-2 (IC50 = 92 nmol / L and 59 nmol / L, respectively). Clinical studies have shown that it has obvious therapeutic effect on non-small cell lung cancer, colon cancer and breast cancer.
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