| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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| Product Name | Best Price Provide CAS 439081-18-2 Afatinib Powder |
| CAS | 439081-18-2 |
| Appearance | White powder |
| Molecular formula | C24H25ClFN5O3 |
| Molecular Weight | N/A |
| Assay | 98% |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of thereceptor tyrosine kinases epidermal grow factor receptor (EGFR) and erbB-2 (HER2).
Afatinib is not only active against EGFR mutations targeted by first generation TKIs like erlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
Afatinib is a drug for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal grow factor receptor (EGFR) and erbB-2 (HER2)
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