| Product Name: |
Febrifugine |
| Description: |
Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by toxicity . |
| CAS: |
24159-07-7 |
| Source: |
The roots of Dichroa febrifuga |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Calculate Dilution Ratios(Only for Reference)
| |
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.319 mL |
16.5948 mL |
33.1895 mL |
66.379 mL |
82.9738 mL |
| 5 mM |
0.6638 mL |
3.319 mL |
6.6379 mL |
13.2758 mL |
16.5948 mL |
| 10 mM |
0.3319 mL |
1.6595 mL |
3.319 mL |
6.6379 mL |
8.2974 mL |
| 50 mM |
0.0664 mL |
0.3319 mL |
0.6638 mL |
1.3276 mL |
1.6595 mL |
| 100 mM |
0.0332 mL |
0.1659 mL |
0.3319 mL |
0.6638 mL |
0.8297 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Adv Pharm Technol Res. 2013 Jan;4(1):50-60. |
| Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent.[Pubmed: 23662282] |
Febrifugine and its derivatives are effective against Plasmodium falciparum.
METHODS AND RESULTS:
Using PHASE algorithm, a five-point pharmacophore model with two hydrogen bond acceptor (A), one positively ionizable (P) and two aromatic rings (R), was developed to derive a predictive ligand-based statistically significant 3D-quantitative structure-activity relationship (QSAR) model (r(2) = 0.972, SD = 0.3, F = 173.4, Q(2) = 0.712, RMSE = 0.3, Person-R = 0.94, and r(2) pred = 0.8) to explicate the structural attributes crucial for antimalarial activity.
CONCLUSIONS:
The developed pharmacophore model and 3D QSAR model can be a substantial tool for virtual screening and related antimalarial drug discovery research. |
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