Gold Member Since 2016
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Wuhan HengHeDa Pharm Co., Ltd.

Nsi-189 Phosphate, Nootropics, Smart Drugs manufacturer / supplier in China, offering Top Nootropics Nsi-189 Free Base, High Quality Pirfenidone CAS: 53179-13-8 in Stock, Pirfenidone CAS: 53179-13-8 for Research Only and so on.

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Top Nootropics Nsi-189 Free Base

FOB Price: US $10-40 / G
Min. Order: 100 G
Min. Order FOB Price
100 G US $10-40/ G
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Port: Shanghai, China
Production Capacity: 100kg/Quater
Payment Terms: L/C, T/T, D/P, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: HHD-NSI-189
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: 98%
  • Trademark: HHD PHARM
  • Specification: 98%+
  • HS Code: 2934999090
  • Powder: Yes
  • Certification: in-House Standard
  • State: Solid
  • Appearance: Solid
  • Transport Package: Aluminum Foil Bag
  • Origin: China
Product Description
Basic information of NSI-189 
Name [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone
Molecular Structure  
Molecular Formula C22H30N4O
Molecular Weight 366.50
CAS Registry Number 1270138-40-3
NSI-189 is an experimental, novel potential antidepressant that is under investigation byNeuralstem, Inc. for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration. Research into NSI-189 has been funded by theDefense Advanced Research Projects Agency (DARPA) and the National Institutes of Health(NIH).The mechanism of action of NSI-189 appears to be activation of neurogenesis in thehippocampus and possible enlargement of this structure,[2] but how the drug mediates these effects is unknown and binding studies have so far failed to identify any certain molecular targets for the drug. As stated by Neuralstem, NSI-189 is a "new chemical entity with [a] novel mechanism of action, molecular target yet unknown, but not mediated by SSRI or SNRIor by BDNF release or via any known GPCRs, kinases, or channels." The drug was discovered via high-throughput screening of a library of 10,269 compounds for neurogenic effects in vitro.

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