Customization: | Available |
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Powder: | Yes |
Customized: | Non-Customized |
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What is Vitamin D Derivative Drugs?
Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.
Calcipotriol is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, producing an elevation in cell differentiation and a reduction in cell proliferation. Although its efficacy is comparable to calcitriol, calcipotriol exhibits at least 100 times less effect on calcium metabolism in rats.
Product Name: | Calcipotriene |
Synonyms: | 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1α,3β,5Z,7E,22E,24S)-;Calciptriol;Daivobet;Daivonex;calcipotriol anhydre ep5.3;(1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol;Calcipotriene;CALCIPOTRIOL - EP |
CAS: | 112965-21-6 |
MF: | C27H40O3 |
MW: | 412.6 |
EINECS: | 601-218-4 |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;-;Isotope Labelled Compounds |
Quality Standard: | EP9.0 |
Molecular Structure: | ![]() |
3)A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.
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