| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
|---|
| Customization: |
|---|
Suppliers with verified business licenses
Audited Supplier
Tarolimus, Tac, or FK506, is a calcineurin inhibitor (CNI) that has been the cornerstone of most immunosuppressive regiments in solid organ transplantation (SOT) since its introduction in the 1990s. The immunosuppressant mechanism of tachlimus is mainly through binding with FK506 receptor binding protein-12 (FKBP-12) in T lymphocytes to form Tac-FKBP-12 complex, which binds with calcineurin and inhibits the activation of the latter, and interferes with and inhibits the synthesis of interleukin 2 (IL-2) at the molecular level. The infiltration of cytotoxic T lymphocytes into the graft is inhibited, so as to prevent and treat rejection. The use of tacrolimus has revolutionized the future of kidney transplantation compared to cyclosporine because it has higher graft survival, higher tolerance, lower incidence of rejection, and fewer side effects. In 2009, KDIGO recommended tacrolimus as a first-line CNI for kidney transplantation as an initial and long-term maintenance immunosuppressive therapy. However, tacrolimus concentration monitoring remains complex, with underuse increasing the risk of rejection and overuse increasing the risk of side effects, mainly nephrotoxicity, neurotoxicity, infection, malignancy, diabetes and gastrointestinal discomfort.The absorption of tacrolimus in the gastrointestinal tract after oral administration is incomplete and varies widely among individuals. Some patients are absorbed rapidly after oral administration, reaching the maximum blood concentration at 0.5h, and some patients peak at 1 to 3h. After absorption, tacrolimus can be widely distributed in the body, with high blood concentration in heart, liver, kidney and other tissues. Tacrolimus is mainly metabolized by the liver, and at least 9 metabolites have been found. Chemicalbook is considered to be the main metabolite of liver microsomes, and it is mainly excreted from the body by bile through feces after metabolism. The therapeutic window of tacrolimus is narrow, the therapeutic dose is close to the toxic dose, and there are great differences in the pharmacokinetic characteristics and bioavailability of different individuals. Therefore, it is necessary to monitor the blood concentration of tacrolimus and adjust the dose according to the monitoring results, so as to reach the target blood concentration within a certain time as soon as possible.
| Model NO. | 104987-11-3 | Colour | white |
| Molecular Formula | C44H69NO12 | Molecular Weight | 227.10 |
| Delivery | 8-10days | Melting Point | 75-77 ºC |
| Transport Package | 25kg/Drum | Specification | 99% |
| Origin | China |
Flash Point | 59 ºC |
Q1: What's your MOQ?
A:It depends on different products,we can accept sample order or provide free sample for your test.
Q2:How about delivery leadtime?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q3: Is there a discount?
A:Different quantity has different discount.
Q4:How to start orders or make payments?
A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Bitcoin.
Q5: How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6. We don't know you at all, how can we trust you?
A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.
Q7.Do you test all your goods before delivery?
A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
Suppliers with verified business licenses
Audited Supplier 
){kind=link}
){kind=link}