Wuhan Hhd Manufacturer Supply High Purity API Powder CAS 877399-52-5 Crizotinib

• Powder: Yes
• Customized: Non-Customized
• Suitable for: Elderly, Adult
• Purity: >99%
• Transport Package: Drum or as Required
• Specification: Customized
• Model NO.: HHD
• Trademark: HHD
• Origin: Hubei China
• Production Capacity: 50000 Pieces Per Years

Product Description

Product Description

 

 

 Despcription
Product Name:Crizotinib
CAS:877399-52-5
MF:C21H22Cl2FN5O
MW:450.343
EINECS:638-814-9
Mol File:877399-52-5.mol  
Melting point:192 °C
Boiling point:599.2±50.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. room temp
pka9.81±0.10(Predicted)
form powder
color white to tan

Application

Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET.
Chemical PropertiesWhite Solid
UsesA potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). A potential antitumor agent.
UsesCrizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
UsesPF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

Company Profile

FAQ