Despcription Product Name:Crizotinib CAS:877399-52-5 MF:C21H22Cl2FN5O MW:450.343 EINECS:638-814-9 Mol File:877399-52-5.mol Melting point:192 °C Boiling point:599.2±50.0 °C(Predicted) Density 1.47±0.1 g/cm3(Predicted) storage temp. room temp pka9.81±0.10(Predicted) form powder color white to tan
Application
Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET. Chemical PropertiesWhite Solid UsesA potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). A potential antitumor agent. UsesCrizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. UsesPF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley
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