Wuhan Hhd Supply Mirabegron Powder Prostaglandin Antagonists/Antagonist Mirabegron CAS No. 223673-61-8

• Powder: Yes
• Customized: Non-Customized
• Suitable for: Adult
• Purity: >98%
• Color: White
• Grade: Pharmaceutical Grade
• Transport Package: Alumininum Foli Bags
• Specification: 10g, 50g, 200g, 1kg, 5kg
• Trademark: hhdpharm
• Origin: China

Product Description

Wuhan HHD Supply Mirabegron Powder Prostaglandin Antagonists/Antagonist Mirabegron CAS No. 223673-61-8 

 

Basic information:

Product Name:	Mirabegron
CAS:	223673-61-8
MF:	C21H24N4O2S
MW:	396.51
EINECS:	800-126-3
Mol File:	223673-61-8.mol

Description:

Mirabegron is for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.

Application

1.Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
2.Uses for A potent bladder relaxant compound
3.Uses for Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.