Hhdpharm Proinsulin C-Peptide (55-89) Human CAS 11097-48-6

• Powder: Yes
• Customized: Customized
• Certification: in-House Standard
• Suitable for: Adult
• State: Solid
• Purity: >98%
• Model NO.: CAS 11097-48-6
• Color: White
• Grade: Pharmaceutical Grade
• Storage: Cool Dry Place
• Sample: Aviailable
• Transport Package: Aluminum Foil Bag
• Specification: 98%+
• Trademark: HHD PHARM
• Origin: China
• HS Code: 2934999090
• Production Capacity: 10kg/Quater

Product Description

High Quality Proinsulin C-Peptide (55-89) human cas 11097-48-6
A fusion gene encoding double-C-peptide human proinsulin was constructed by insertion of a DNA fragment encoding human C-peptide into the 5'-terminal C-peptide coding sequence of a synthetic human proinsulin gene with correct reading frame and over-expressed in E. coli. The purified double-C-peptide human proinsulin shows decreased activity in receptor binding and insuli n immune assays as compared with human proinsulin. Disulphide bond reconstitution studies demonstrate that there is not much more influence of the protein concentration on the yield of refolded double-C-peptide human proinsulin. The double-C-peptide human proinsulin shows a 1.86-fold human C-peptide immune activity as compared with that of human proinsulin and gives a good yield of the molecule with correct disulphide bonds in reconstitution studies strongly suggesting the existence of very flexible conformation of the C-peptide.
 

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