| Powder: | Yes |
|---|---|
| Customized: | Customized |
| Certification: | ISO 9001 |
| Suitable for: | Elderly |
| State: | Solid |
| Purity: | >99% |
| Customization: |
|---|
Suppliers with verified business licenses
Audited Supplier | CAS No. | 107007-99-8 |
|---|---|
| Product Name | Granisetron hydrochloride |
| Molecular Formula | C18H24N4O • HCl |
| Molecular Weight | 348.9 g/mol |
| IUPAC Name | 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride |
| Standard InChI | InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H |
| Standard InChIKey | QYZRTBKYBJRGJB-WQTKJZBYSA-N |
| Isomeric SMILES | CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl |
| SMILES | CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl |
| Canonical SMILES | CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl |
| Appearance | Assay:≥98%A crystalline solid |
| Description | Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.Granisetron blocks the delayed rectifier current (IK) of feline isolated ventricular myocytes with a KD of 4.3 mM. Granisetron shows an intrinsic voltage-dependence as the block increases with depolarization. Granisetron blocks from the intracellular side at a binding site located 10% across the transmembrane electrical field. Granisetron (3 mM) prolongs the action potential duration (APD) by about 30% at 0.5 Hz in feline isolated ventricular myocytes.Granisetron provides a substantial benefit against cisplatin-induced emesis in the piglet, some animals being completely protected during both the acute and the delayed phases. |
| Related CAS | 109889-09-0 (Parent) |
| Synonyms | 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide BRL 43694 BRL 43694A BRL-43694 BRL-43694A BRL43694 BRL43694A Granisetron Granisetron Hydrochloride Granisetron Monohydrochloride Hydrochloride, Granisetron Kytril Monohydrochloride, Granisetron |
| PubChem Compound | 65264 |
| Last Modified | Nov 11 2021 |
FAQ
Q1: Can i get some samples?
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