| Powder: | Yes |
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| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Audited Supplier Product Name: Flurbiprofen
Synonyms: 1'-biphenyl)-4-aceticacid,2-fluoro-alpha-methyl-(;1'-biphenyl]-4-aceticacid,2-fluoro-alpha-methyl-[;2-(2-Fluoro-4-biphenyl)propionicacid;2-(2-fluoro-4-biphenylyl)propionicacid;2-fluoro-alpha-methyl-4-biphenylaceticaci;(+/-)-FLURBIPROFEN;FLURBIPROFEN;ANSAID
CAS: 5104-49-4
MF: C15H13FO2
MW: 244.27
EINECS: 225-827-6
Product Categories: ANSAID;Other APIs;Intermediates & Fine Chemicals;API's;Aromatics;API;Pharmaceuticals
Mol File: 5104-49-4.mol
Flibanseri n , also known as flurbiprofen, flurbiprofen, is a potent Phenylalanine anti-inflammatory and antipyretic analgesics,it can inhibit prostaglandin synthesizing cyclooxygenase to have analgesic, anti-inflammatory and antipyretic effects. Its anti-inflammatory and analgesic effects are 250 times and 50 times of aspirin (also known as acetylsalicylic acid) . The oral absorption is rapid , peak plasma concentration achieves after 1.5 hours , half-life is 3.5 hours, it has wide tissue distribution, PPB is 99.4%, it can compete with drugs having a high plasma protein binding rate to bind plasma protein .it Metabolizes in the liver and becomes flurbiprofen hydroxy and its aldehyde acid conjugates. T1/2 is 3.5 h. Urine and fecal excretion,account for approximately 60% and 40% respectively . Age has no effect on drug metabolism. It is Mainly used for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. It is also used in preventing aphakic cystoid patchy edema After surgical removal of the lens, inhibiting pupillary constrictionsurgery, treatment of inflammation after cataract and trabeculoplasty arg on laser eye surgery. It Also applies to pain caused by some other reasons such as trauma, sprains, surgery.
Flurbiprofen CAS 5104-49-4 of Chemical Properties
Melting point 110-112 °C(lit.)
Boiling point 376.2±30.0 °C(Predicted)
density 1.1795 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility methano l: soluble50mg/mL
form White solid
pka pKa 3.80(H2O) (Uncertain)
color white to off-white
Water Solubility 8mg/L(room temperature)
Merck 14,4199
InChIKey SYTBZMRGLBWNTM-UHFFFAOYSA-N
CAS DataBase Reference 5104-49-4(CAS DataBase Reference)
EPA Substance Registry System [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-?-methyl- (5104-49-4)
Function and Application of Flurbiprofen CAS 5104-49-4
1. Flurbiprofen is anti-inflammatory drug for chronic arthritis and pain, inflammation of Deformation joint disease , and pain after surgery and tooth extraction. Mouse oral LD50 of 140mg/kg, rats 640-800mg/kg.
1.COA/MSDS/ROS/MOA Available.
2.Any inquiries will be replied within 12 hours.
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