| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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| Description | |
|---|---|
| Overview | A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available. |
| Brand Family | Calbiochem® |
| Synonyms | MDM2 Inhibitor IV |
1.COA/MSDS/ROS/MOA Available.
2.Any inquiries will be replied within 12 hours.
3. Dedication to quality, supply & service.
4.Strictly on selecting raw materials.
5.Reasonable & competitive price, fast lead time.
6.Faster delivery:Sample order in stock and one week for bulk production.
7.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8.Timely after-service resolves your worry for internation trade.
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