Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.
Description
Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
Product Name: |
Paricalcitol |
Synonyms: |
PARICALCITOL (10 MG)F0E3030.997MG/MG(AI);
19-nor-1alpha,25-dihydroxyvitamin D2;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;
Zemplar; |
CAS: |
131918-61-1 |
Molecular Structure: |
|
Appearance |
White or off-white powder |
MF: |
C27H44O3 |
MW: |
416.64 |
EINECS: |
658-064-6 |
Product Categories: |
Vitamin D3 analogs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
Fp |
14ºC |
Form |
Neat |
InChIKey |
BPKAHTKRCLCHEA-UBFJEZKGSA-N |
Quality Standard |
USP41 |
1) Synthetic analog of vitamin D. Antihyperparathyroid.
2) Antihyperparathyriod
3) 1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Function
It is used for the prevention and treatment of SHPT, and the prevention and treatment of SHPT in patients with stage III and IV chronic kidney disease (CKD) before dialysis and transplantation.
Only for Research & Lab Use,not for human use.
We also supply the following small molecule chemical compounds as follows:
Packaging & Shipping
Our service
1.COA/MSDS/ROS/MOA Available.
2.Any inquiries will be replied within 12 hours.
3. Dedication to quality, supply & service.
4.Strictly on selecting raw materials.
5.Reasonable & competitive price, fast lead time.
6.Faster delivery:Sample order in stock and one week for bulk production.
7.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8.Timely after-service resolves your worry for internation trade.
9.Payment: