Hhdpharm Paricalcitol CAS 131918-61-1 with High Purity 99.0%Min. Small Molecule Compounds Secondary Hyperparathyroidism

• Powder: Yes
• Customized: Non-Customized
• Certification: Enterprise Standards
• Suitable for: Adult
• State: Powder
• Purity: >98%
• Model NO.: CAS 131918-61-1
• Color: White
• Grade: Pharmaceutical Grade
• Shelf Life: 2 Years
• Model No: Hhd
• Transport Package: Alumininum Foli Bags
• Specification: 10g, 50g, 200g, 1kg, 5kg
• Trademark: hhdpharm
• Origin: China

Product Description

Active vitamin D drugs are a general term for a series of vitamin D2/D3 derivatives, commonly referred to as "calciferol" drugs. These compounds are complex in structure and involve techniques such as photochemistry and microbial transformation. They are difficult to synthesize, sensitive to light and oxygen, and the API in the preparation is microgram-level, and the development threshold is high. Clinically used mainly for the treatment of osteoporosis, secondary hyperparathyroidism and psoriasis.

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo. 

Product Name:	Paricalcitol
Synonyms:	PARICALCITOL (10 MG)F0E3030.997MG/MG(AI); 19-nor-1alpha,25-dihydroxyvitamin D2;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; Zemplar;
CAS:	131918-61-1
Molecular Structure:
Appearance	White or off-white powder
MF:	C27H44O3
MW:	416.64
EINECS:	658-064-6
Product Categories:	Vitamin D3 analogs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals

Fp	14ºC
Form	Neat
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
Quality Standard	USP41

 

1) Synthetic analog of vitamin D. Antihyperparathyroid.

2) Antihyperparathyriod
3) 1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.



It is used for the prevention and treatment of SHPT, and the prevention and treatment of SHPT in patients with stage III and IV chronic kidney disease (CKD) before dialysis and transplantation.

 

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