| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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Trans ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction.
Trans ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. Trans ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. Trans ISRIB enhances cognitive memory in rodents.
Trans ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.
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Product name
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Trans ISRIB
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CAS No.
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1597403-47-8
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Other Names
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ISRIB
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MF
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C22H24CI2N2O4
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EINECS No.
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N/A
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Place of Origin
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China
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Type
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Pharmaceutical Intermediates
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Grade Standard
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Medicine Grade
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Brand Name
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GREENYO
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Purity
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99%min HPLC
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Appearance
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White Powder
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Application
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For research, Intermediates
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1. Trans ISRIB powder has vasodilating, blood thinning, and memory-enhancing actions.
2. Trans ISRIB powder acts as a cerebral stimulant and vasodilator.
3. Trans ISRIB powder is used to treat arteriosclerosis.
4. Trans ISRIB powder is very effective in curing dementia caused due to insufficient blood supply to the brain.
5. Trans ISRIB powder interferes with cells' ability to synthesize DNA and RNA.
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