Wuhan Hhd Supply GMP Pharmaceutical Gefitinib Powder API High Purity CAS 184475-35-2

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: HHD Pharm
• Certification: Enterprise Standards
• Suitable for: Adult
• State: Powder
• Purity: >98%
• Color: White
• Grade: Pharmaceutical Grade
• Test Method: HPLC,Lcms,Hnmr
• COA: Available
• Transport Package: Alumininum Foli Bags
• Specification: 10g, 50g, 200g, 1kg, 5kg
• Trademark: hhdpharm
• Origin: China

Product Description

Wuhan HHD Supply GMP Pharmaceutical Gefitinib Powder API High Purity CAS 184475-35-2

Product Name:Gefitinib
Molecular Formula: C22H24ClFN4O3
Molecular Weight: 446.9
CAS: 184475-35-2
Appearance: White or almost-white crystalline powder

Gefitinib is the first selective inhibitor of epidermal grow factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.
 

 

 

Packaging & Shipping

Our service

1.COA/MSDS/ROS/MOA Available.
2.Any inquiries will be replied within 12 hours.
3. Dedication to quality, supply & service.
4.Strictly on selecting raw materials.
5.Reasonable & competitive price, fast lead time.
6.Faster delivery:Sample order in stock and one week  for bulk production.
7.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8.Timely after-service resolves your worry for internation trade.
9.Payment: