| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Non-Customized |
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|
Product Name |
Darolutamide |
|
Purity |
99% |
|
CAS No. |
1297538-32-9 |
|
Molecular Formula |
C19H19ClN6O2 |
|
Molecular Weight |
398.85 |
|
Appearance |
white powder |
|
Shelf life |
24 months under the previously mentioned conditions. |
|
Storage |
Store in a cool dry place, avoiding sunlight directly. |
ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.
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