1.Paeoniflorin Overview
Paeoniflorin is a derivative of monoterpene, mainly derived from dried root of plant white peony (accounting for 3% of white peony). It is a main effective ingredient of total glucosides of paeonia (TPG). Both of them are natural cosmetic raw materials. Paeoniflorin is off-white fine powder. It's lightly soluble in water, and soluble in ethanol and acetone. Paeoniflorin is hydrolyzed and polymerized in a dilute alkali solution; and it will slowly degrade in a slightly acidic aqueous solution. Emulsions made of non-ionic surfactants can slow down this process.
Paeoniflorin has great development prospect in market of cosmetic raw material, because of its various biological activities. Paeoniflorin is characterized by scavenging free radicals and resisting oxidative damage. It inhibits NF-kB cells and improves immune property of skin cells. It greatly exerts anti-inflammatory effect. Thus Paeoniflorin can be used in combination with other effective ingredients to treat skin sores, acne, pimple, sunburn and so on. Paeoniflorin inhibits melanin production due to its anti-oxidation and anti-inflammatory activities. It reduces skin pigmentation; and it has a non-dose-dependent whitening effect. In addition, Paeoniflorin can prevent and improve intrinsic skin aging and UV-induced skin aging. It has an anti-wrinkle effect.
| Product Name |
CAS Number |
INCI |
| Paeoniflorin |
23180-57-6 |
PEONIFLORIN |
| Molecular Weight |
Molecular Formula |
Molecular Structure |
| 480.45g/mol |
C23H28O11 |
|
2. Paeoniflorin Source
White peony (Latin name: Cynanchum otophyllum) is a plant of Paeonia genus in Paeoniaceae family. It is native to central and eastern Asia; and now it grows in temperate regions all over the world. It also is a Chinese herbal plant. It is distributed in mountainous areas, valley woodlands or hillsides at an altitude of 1500-2800 meters. In China, it is mainly distributed in Zhejiang, Anhui, Guizhou, Yunnan, Sichuan and Tibet provinces. Its main active ingredients are monoterpenoids, phenols, tannins, sterols, flavonoids, volatile oils, amino acids, proteins and other compounds. Paeoniflorin is a principal active ingredient in dried roots of Paeoniae; it has many biological activities such as anti-inflammatory and anti-oxidation. Therefore, it is widely used in cosmetics and pharmaceutical industries.
3. Paeoniflorin Manufacturer Specifications
| Product Name |
Specification |
| Paeoniflorin |
10%-98% |
Paeoniflorin 70% Specifications
| Items |
Specification |
| Assay |
≥70.00% |
| Appearance |
Off-white fine powder |
| Odor |
Characteristic |
| Taste |
Characteristic |
| Used part |
Root |
| Physical Characteristics |
| Particle size |
98%through 80 mesh |
| Loss on drying |
≤5.00% |
| Ash content |
≤5.00% |
| Density |
0.40-0.70g/ml |
| Heavy Metals |
| Heavy metals |
≤10ppm |
| As |
≤2ppm |
| Pb |
≤2ppm |
| Hg |
≤1ppm |
| Microbiological Tests |
| Total Plate count |
≤1000cfu/g |
| Yeast & mold |
≤100cfu/g |
| Escherichia coli |
Negative |
| Staphylococcus |
Negative |
| Salmonella |
Negative |
Paeoniflorin 98% Specifications
| Items |
Specification |
| Paeoniflorin |
≥98% |
| Test method |
HPLC |
| Appearance |
White or off-white powder |
| Odor |
Characteristic |
| Physical Characteristics |
| Boiling point |
684_9ºC at 760mmHg |
| Partical Size |
98% through 80 Mesh |
| MoistureContent |
≤1% |
| Total Ash Content |
≤0.1% |
| Solvent residue |
≤3000PPM |
| Heavy Metals |
| Heavy metals |
≤10ppm |
| As |
≤2ppm |
| Pb |
≤2ppm |
| Microbiological Tests |
| Total Plate count |
≤1000cfu/g |
| Yeast & mold |
≤100cfu/g |
| Escherichia coli |
Negative |
| Staphylococcus |
Negative |
| Salmonella |
Negative |
4. Paeoniflorin Manufacturer Flow Chart
5. Paeoniflorin Benefits
1.Anti-inflammation
Paeoniflorin exerts an anti-inflammatory effect by inhibiting production of TNF-α and IL-1β and promoting expression of IL-10. The study result indicates that Paeoniflorin antagonizes chemokine formation induced by TNF-α and leukocyte migration. Therefore, Paeoniflorin shows a broad spectrum of anti-inflammatory property.
2.Anti-wrinkle & anti-aging
Paeoniflorin can enhance vitality and performance of skin cells. It promotes collagen fibers' synthesis. Thereby Paeoniflorin contributes to increasing of toughness and elasticity of skin tissue; also it reduces production of lipid peroxides. Accordingly, Paeoniflorin significantly prevents intrinsic skin aging as well as DNA damage and skin wrinkling caused by UV. And compared with vitamin E, Paeoniflorin can better increase cell growth rate. Therefore, cosmetics containing Paeoniflorin are very effective anti-aging products.
| Cell |
Treatment (M) |
Cell growth rate |
Cell mortality rate |
Cell aging rate |
| keratinocytes |
Blank |
- |
- |
- |
| Paeoniflorin 0.0005M |
55.3% |
12.3% |
24.7% |
| Vitamin E 0.0004M |
23.3% |
10.5% |
20.1% |
| Fibroblast |
Blank |
- |
- |
- |
| Paeoniflorin 0.0005M |
18.4% |
11.5% |
17.2% |
| Vitamin E 0.0004M |
9.96% |
15.4% |
22.8% |
6. Study on the Pharmacology of Paeoniflorin Cosmetics
| Test item |
Concentration |
Result |
| Elimination to hydroxyl radicals |
60.3μg/mL |
Elimination rate:46.7% |
| Inhibition to cell apoptosis induced by hydrogen peroxide |
10μmol/L |
Inhibition rate:40% |
| Inhibition to IL-2 production |
2.5g/kg |
Inhibition rate:34.4% |
| Inhibition to IL-6 production |
2.5g/kg |
Inhibition rate:24.8% |
| Inhibition to IL-10 production |
2.5g/kg |
Inhibition rate:80.2% |
| Inhibition to MMP-9 activity |
0.01mmol/L |
Inhibition rate:30.0% |
| Inhibition to NF-kB cell activity |
100μg/mL |
Inhibition rate:53.2% |
7. Paeoniflorin Reference Formula
Skin-care cream
| Phase |
Ingredient |
Content (%) |
Ingredient |
Content (%) |
| A |
Paeoniflorin |
4 |
Pearl hydrolysate |
10 |
| Grape seed oil |
1.5 |
β-glucan |
8 |
| Bee pollen |
0.2 |
Leucine |
2 |
| Lysine |
2 |
Aloe extract |
8 |
| B |
Span-60 |
2 |
Tween-60 |
1 |
| Imidazolidinyl urea |
0.1 |
|
|
| C |
Refined cottonseed oil |
7 |
|
|
| D |
Fragrance |
0.4 |
|
|
| E |
Octadecanol |
2 |
Sorbitol Solution(70) |
3 |
| Deionized water |
Add to 100 |
|
|
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