Factory Supply API Abt-199 CAS 1257044-40-8 Venetoclax

• Powder: Yes
• Customized: Non-Customized
• State: Solid
• Purity: >98%
• Transport Package: Al-Foil Bag
• Specification: 1bags
• Model NO.: CAS 1257044-40-8
• Trademark: HHD
• Origin: China
• Production Capacity: 1000bags

Product Description

 

Product Description

 

API  Abt-199   cas 1257044-40-8 Venetoclax Powder 

Product Name:    ABT-199
CAS:    1257044-40-8
MF:    C45H50ClN7O7S
MW:    868.44
EINECS:    820-130-9
density     1.340±0.06 g/cm3 
form     Yellow solid.

What is Venetoclax
 ABT-199, also known as venetoclax used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line treatment drug of CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets. It also has the potential for the treatment of ER-positive breast cancer. 

Venetoclax function 
Venetoclax was approved in the US for treatment of patients with chronic lymphocytic leukemia (CLL). Venetoclax functions as a selective inhibitor of B cell lymphoma subtype 2 (BCL-2) 
Venetoclax is  for similar indications  for the treatment of non-Hodgkin lymphomas (NHL), acute myeloid leukemia (AML), multiple myeloma (MM), and several other disorders, either as a combination therapy or a stand-alone treatment. 

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