Wuhan Hhd Supply Abrocitinib PF-04965842 Pharmaceutical Apis CAS 1622902-68-4

• Powder: Yes
• Customized: Non-Customized
• Suitable for: Adult
• Purity: >98%
• Color: White
• Grade: Pharmaceutical Grade
• Model NO.: CAS 1622902-68-4
• Transport Package: Alumininum Foli Bags
• Specification: 10g, 50g, 200g, 1kg, 5kg
• Trademark: hhdpharm
• Origin: China

Product Description

Wuhan HHD Supply Abrocitinib PF-04965842 Pharmaceutical APIs CAS 1622902-68-4

 

Basic information:

 

Product name	Alpelisib/BYL-719
CAS No.	1217486-61-7
Molecular formula	C19H22F3N5O2S
Molecular weight	441.47
Purity	99%
Appearance	White or almost white powder
Package	Aluminum Bag;Drums
Shelf life	2 years

Description:

Alpelisib is used for advanced solid tumours. Alpelisib shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients.