Basic information of Dihexa
N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa)
|Chemical name:||N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa)|
|Melting Point:||>209°C (dec.)|
|Storage:||Hygroscopic, Refrigerator, under inert atmosphere|
|Solubility:||DMSO (Slightly), Methanol (Slightly)|
|Stability:||No Data Available|
|Category:||No Data Available|
|Boiling Point:||No Data Available|
|Applications:||N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.|
|References:||McCoy, A., et al.: J. Pharm. Exp. Ther., 344, 141 (2013)|
|Dangerous Goods Info:||NA|
Dihexa , also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models ofAlzheimer's disease-like mental impairment. In an assay of neurotrophicactivity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
According to a patent, "Short duration safety studies with Dihexa have uncovered no apparenttoxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as anoncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation.