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Wuhan HengHeDa Pharm Co., Ltd.

Pimecrolimus, 137071-32-0, Apis manufacturer / supplier in China, offering Pimecrolimus CAS No. 137071-32-0, 2-Ethylbenzofuran-3-Yl P-Methoxyphenyl Ketone CAS3343-80-4, Benzarone CAS1477-19-6 Pharmaceutical Grade Research Chemicals and so on.

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Supplier Homepage Product APIs Pimecrolimus CAS No. 137071-32-0

Pimecrolimus CAS No. 137071-32-0

FOB Price: US $1-2 / Piece
Min. Order: 100 Pieces
Min. Order FOB Price
100 Pieces US $1-2/ Piece
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Transport Package: Alumininum Foli Bags
Payment Terms: T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: HHD-PHARM
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >98%
  • Grade: Pharmaceutical Grade
  • Specification: 10g, 50g, 200g, 1kg, 5kg
  • Powder: Yes
  • Certification: Enterprise Standards
  • State: Powder
  • Color: White
  • Trademark: hhdpharm
  • Origin: China
Product Description

1.Base Date of Pimecrolimus

 Name:Pimecrolimus

 Purity:99%

 Molecular formular:C43H68ClNO11

2. Details of Pimecrolimus

Superlist Name:Pimecrolimus

Molecular Formula:C43H68ClNO11

CAS No.:137071-32-0 

Purity:99%

Synonyms:SDZ-ASM 981; Elidel

Molecular Weight:810.45

Appearance:white powder

PortSH

Application:Pharmaceutical Intermediates

 

 

4.Description of Pimecrolimus

Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).Presumably through these Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase).Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells.Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils.These eactions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells.Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells, and the activation of eosinophils.These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis


 

Pimecrolimus CAS No. 137071-32-0

Pimecrolimus CAS No. 137071-32-0

Pimecrolimus CAS No. 137071-32-0
Pimecrolimus CAS No. 137071-32-0

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